{"id":34466,"date":"2024-11-26T16:34:32","date_gmt":"2024-11-26T16:34:32","guid":{"rendered":"https:\/\/bnssghealthiertogether.org.uk\/?page_id=34466"},"modified":"2025-01-16T10:16:57","modified_gmt":"2025-01-16T10:16:57","slug":"athena-amitritypline-for-the-prevention-of-post-herpetic-neuralgia","status":"publish","type":"page","link":"https:\/\/bnssghealthiertogether.org.uk\/ro\/integrated-care-board\/research-and-evidence\/our-research-portfolio\/nihr-funded-projects\/athena-amitritypline-for-the-prevention-of-post-herpetic-neuralgia\/","title":{"rendered":"ATHENA: Amitritiplin\u0103 pentru prevenirea nevralgiei postherpetice"},"content":{"rendered":"<div class=\"assembler_default-group assembler_module_group assembler_default-group_1 assembler_module_group_1\"><div class=\"assembler_module_area assembler_module_area_1\"><div class=\"assembler_text-module assembler_module assembler_text-module_1 assembler_module_1  transparent\"><a tabindex=\"-1\" title=\"Sec\u021biunea intitulat\u0103 modul-1\" id=\"module-1\" href=\"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/pages\/34466\/#module-1\" class=\"anchor\"><span class=\"hidden\">Sec\u021biunea intitulat\u0103 modul-1<\/span><\/a><!-- Template found for text-module - Template: template-text - Matched: _only --><section class=\"w-full mx-auto max-w-content pt-12 sm:pt-24 pb-12 sm:pb-24\">\r\n  <div class=\"entry-content w-full !px-0 max-w-small\">\r\n        <header class=\"local_header\">\n<div class=\"local_header__inner\">\n<h1 class=\"local_header__title\">ATHENA: Amitritiplin\u0103 pentru prevenirea nevralgiei postherpetice<\/h1>\n<\/div>\n<\/header>\n<article class=\"page_content\">\n<h2><\/h2>\n<h2 class=\"page_content__inner\">Finan\u021bare<\/h2>\n<\/article>\n<p>Institutul Na\u021bional pentru S\u0103n\u0103tate (NIHR) Evaluarea Tehnologiilor Medicale (HTA) Ref. NIHR129720<\/p>\n<h2>Care este \u00eentrebarea de cercetare?<\/h2>\n<p>Care este eficacitatea amitriptilinei profilactice \u00een doze mici pentru prevenirea nevralgiei postherpetice la pacien\u021bii diagnostica\u021bi cu herpes zoster?<\/p>\n<h2>Care este problema?<\/h2>\n<p>Zona zoster este cauzat\u0103 de acela\u0219i virus care provoac\u0103 varicela. Acesta \u201cdoarme\u201d \u00een celulele nervoase timp de decenii. C\u00e2nd se \u201ctreze\u0219te\u201d, poate provoca o stare general\u0103 de r\u0103u, provoc\u00e2nd furnic\u0103turi sau durere \u00eentr-o parte a corpului, urmate c\u00e2teva zile mai t\u00e2rziu de o erup\u021bie cutanat\u0103. Vindecarea erup\u021biei cutanate poate dura p\u00e2n\u0103 la 4 s\u0103pt\u0103m\u00e2ni.<\/p>\n<p>Medicamentele antivirale ajut\u0103 la reducerea durerii ini\u021biale \u0219i a severit\u0103\u021bii erup\u021biei cutanate. Unele persoane pot avea \u201cdureri nervoase\u201d numite nevralgie postherpetic\u0103 la c\u00e2teva luni dup\u0103 dispari\u021bia erup\u021biei cutanate cauzate de zona zoster. Nu avem niciun tratament pentru a preveni acest lucru.<\/p>\n<p>Pacien\u021bii cump\u0103r\u0103 analgezice precum paracetamolul, iar medicii de familie le prescriu, dar acestea adesea nu ajut\u0103. Amitriptilina este un medicament vechi, utilizat ini\u021bial \u00een doze mari (75-150 mg) pentru tratarea depresiei, dar acum este utilizat \u00een doze mici pentru durerile nervoase. Un studiu de mici dimensiuni, publicat \u00een 1997, a sugerat c\u0103 administrarea timpurie a unei doze mici (25 mg) de amitriptilin\u0103 poate ajuta la prevenirea nevralgiei postherpetice.<\/p>\n<h2>Care este scopul cercet\u0103rii?<\/h2>\n<p>Dorim s\u0103 realiz\u0103m un studiu mai amplu pentru a afla dac\u0103 utilizarea amitriptilinei la prima apari\u021bie a erup\u021biei cutanate previne durerea ulterioar\u0103. Dac\u0103 \u00eenceperea tratamentului cu amitriptilinei din timp ajut\u0103, este un medicament ieftin care ar preveni durerea prelungit\u0103 \u0219i dificil de tratat pentru mii de oameni.<\/p>\n<p>Cu toate acestea, amitriptilina provoac\u0103 frecvent efecte secundare precum ame\u021beli, usc\u0103ciunea gurii \u0219i constipa\u021bie. De asemenea, poate cauza probleme atunci c\u00e2nd este utilizat\u0103 \u00eempreun\u0103 cu alte medicamente. Acest studiu este necesar pentru a ne asigura c\u0103 orice beneficii dep\u0103\u0219esc efectele negative.<\/p>\n<h2>Cum se va realiza acest lucru?<\/h2>\n<p>Vom recruta 846 de persoane cu v\u00e2rsta peste 50 de ani, diagnosticate de medicul lor de familie cu zona zoster \u00een decurs de 72 de ore de la apari\u021bia erup\u021biei cutanate.<\/p>\n<p>Vom ruga pe to\u021bi s\u0103 ia comprimate \u00een fiecare sear\u0103, timp de 10 s\u0103pt\u0103m\u00e2ni: jum\u0103tate dintre participan\u021bi vor primi amitriptilin\u0103, iar cealalt\u0103 jum\u0103tate va primi comprimate placebo (sau \u201cf\u0103r\u0103 comprimate\u201d).<\/p>\n<p>Nici pacien\u021bii, nici medicii lor nu pot alege \u00een ce grup se afl\u0103. Aceasta se va face printr-un proces computerizat numit \u201crandomizare\u201d \u2013 ca \u0219i cum s-ar da cu zarul pentru a decide. \u00cen acest fel, rezultatele nu pot fi afectate de convingerile nim\u0103nui despre amitriptilin\u0103.<\/p>\n<p>Toate celelalte \u00eengrijiri vor fi acelea\u0219i \u2013 medicii de familie vor prescrie antivirale \u0219i analgezice, dac\u0103 este necesar. Vom folosi chestionare pentru a \u00een\u021belege ce se \u00eent\u00e2mpl\u0103 cu fiecare persoan\u0103 \u00een urm\u0103toarele 12 luni, \u00een special dac\u0103 mai au dureri legate de zona zoster la 3 luni.<\/p>\n<h2>Cine conduce cercetarea?<\/h2>\n<p>Dr. Matthew Ridd, medic generalist \u0219i conferen\u021biar \u00een asisten\u021b\u0103 medical\u0103 primar\u0103, \u0218tiin\u021be ale s\u0103n\u0103t\u0103\u021bii popula\u021biei, Universitatea din Bristol.<\/p>\n<h2>Informa\u021bii suplimentare:<\/h2>\n<p><a href=\"https:\/\/research-information.bris.ac.uk\/en\/persons\/matthew-j-ridd\" target=\"_blank\" rel=\"nofollow noopener\">Dr. Matthew Ridd<\/a><\/p>\n<p>Pentru mai multe informa\u021bii sau pentru a v\u0103 implica \u00een acest proiect, trimite\u021bi un e-mail la <a href=\"mailto:bnssg.research@nhs.net\" target=\"_blank\" rel=\"noopener\">bnssg.research@nhs.net<\/a>.<\/p>\n<p>Opiniile exprimate sunt cele ale autorului (autorilor) \u0219i nu neap\u0103rat cele ale NIHR sau ale Departamentului de S\u0103n\u0103tate \u0219i Asisten\u021b\u0103 Social\u0103.<\/p>\n  <\/div>\r\n  <\/section><\/div><!-- .assembler_text-module.assembler_module.assembler_text-module_1.assembler_module_1..transparent --><\/div><!-- .assembler_module_area.assembler_module_area_1 --><\/div><!-- .assembler_default-group.assembler_module_group.assembler_default-group_1.assembler_module_group_1  -->","protected":false},"excerpt":{"rendered":"<p>Section titled module-1 ATHENA: AmiTritypline for the prevention of post-HErpetic NeuralgiA Funding National Institute for Health (NIHR) Health Technology Assessment (HTA) Ref. NIHR129720 What is the research question? What is the effectiveness of prophylactic low-dose amitriptyline for the prevention of post-herpetic neuralgia in patients diagnosed with herpes zoster? What is the problem? Shingles is caused [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":32881,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"class_list":["post-34466","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/pages\/34466","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/comments?post=34466"}],"version-history":[{"count":3,"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/pages\/34466\/revisions"}],"predecessor-version":[{"id":36104,"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/pages\/34466\/revisions\/36104"}],"up":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/pages\/32881"}],"wp:attachment":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/media?parent=34466"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/tags?post=34466"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}