{"id":34548,"date":"2024-11-26T16:46:57","date_gmt":"2024-11-26T16:46:57","guid":{"rendered":"https:\/\/bnssghealthiertogether.org.uk\/?page_id=34548"},"modified":"2025-01-16T22:41:05","modified_gmt":"2025-01-16T22:41:05","slug":"the-effectiveness-and-cost-effectiveness-of-coenzyme-q10-in-heart-failure-with-reduced-ejection-fraction-a-pragmatic-patient-centred-data-enabled-trial-in-primary-care-coral","status":"publish","type":"page","link":"https:\/\/bnssghealthiertogether.org.uk\/ro\/integrated-care-board\/research-and-evidence\/our-research-portfolio\/nihr-funded-projects\/the-effectiveness-and-cost-effectiveness-of-coenzyme-q10-in-heart-failure-with-reduced-ejection-fraction-a-pragmatic-patient-centred-data-enabled-trial-in-primary-care-coral\/","title":{"rendered":"Eficacitatea \u0219i rentabilitatea coenzimei Q10 \u00een insuficien\u021ba cardiac\u0103 cu frac\u021bie de ejec\u021bie redus\u0103: un studiu pragmatic, centrat pe pacient, bazat pe date, \u00een asisten\u021ba medical\u0103 primar\u0103 (CORAL)"},"content":{"rendered":"
Sec\u021biunea intitulat\u0103 modul-1<\/span><\/a>
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Eficacitatea \u0219i rentabilitatea coenzimei Q10 \u00een insuficien\u021ba cardiac\u0103 cu risc redus
\nfrac\u021bia de ejec\u021bie: un studiu pragmatic, centrat pe pacient, bazat pe date, \u00een asisten\u021ba medical\u0103 primar\u0103 (CORAL)<\/h1>\n

 <\/p>\n

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Finan\u021bare<\/h2>\n<\/article>\n

Institutul Na\u021bional pentru Cercetare \u00een S\u0103n\u0103tate \u0219i \u00cengrijire (NIHR) Evaluarea Tehnologiilor Medicale (HTA) Ref. NIHR152257.<\/p>\n

Care este problema?<\/h2>\n

Insuficien\u021ba cardiac\u0103 \u00eenseamn\u0103 c\u0103 inima nu poate pompa s\u00e2ngele corect, fie pentru c\u0103 este prea sl\u0103bit\u0103, fie pentru c\u0103 este prea rigid\u0103. Persoanele cu insuficien\u021b\u0103 cardiac\u0103 se simt adesea dificult\u0103\u021bi de respira\u021bie \u0219i oboseal\u0103. Li se umfl\u0103 picioarele \u0219i gleznele. Aceste simptome pot duce la o calitate a vie\u021bii precar\u0103.<\/p>\n

Persoanele cu insuficien\u021b\u0103 cardiac\u0103 \u0219i profesioni\u0219tii lor din domeniul s\u0103n\u0103t\u0103\u021bii spun c\u0103 cercetarea pentru a \u00een\u021belege ce poate \u00eembun\u0103t\u0103\u021bi calitatea vie\u021bii este cea mai important\u0103 pentru ei.<\/p>\n

Insuficien\u021ba cardiac\u0103 este diagnosticat\u0103 prin intermediul unei scan\u0103ri a inimii (ecocardiogram\u0103). Aceasta m\u0103soar\u0103 \u201cfrac\u021bia de ejec\u021bie\u201d \u2013 cantitatea de s\u00e2nge care este eliminat\u0103 din camera principal\u0103 de pompare a inimii la fiecare b\u0103taie a inimii.<\/p>\n

Unele persoane cu insuficien\u021b\u0103 cardiac\u0103 au o frac\u021bie de ejec\u021bie normal\u0103, dar aceast\u0103 cercetare se concentreaz\u0103 pe persoanele cu insuficien\u021b\u0103 cardiac\u0103 cu o frac\u021bie de ejec\u021bie redus\u0103.<\/p>\n

Care este scopul cercet\u0103rii?<\/h2>\n

Scopul principal al studiului este de a afla dac\u0103 coenzima Q10 \u00eembun\u0103t\u0103\u021be\u0219te calitatea vie\u021bii. Coenzima Q10 este o substan\u021b\u0103 asem\u0103n\u0103toare vitaminelor, care se g\u0103se\u0219te \u00een mod natural \u00een organism \u0219i \u00een unele alimente.<\/p>\n

Dorim s\u0103 realiz\u0103m un studiu pentru a afla dac\u0103 administrarea de coenzim\u0103 Q10 este benefic\u0103 pentru persoanele cu insuficien\u021b\u0103 cardiac\u0103 \u0219i frac\u021bie de ejec\u021bie redus\u0103.<\/p>\n

Cum se va realiza acest lucru?<\/h2>\n

Vom afla acest lucru rug\u00e2nd participan\u021bii s\u0103 completeze chestionare. Chestionarele vor \u00eentreba despre calitatea vie\u021bii lor \u0219i despre via\u021ba de zi cu zi (Chestionarul privind cardiomiopatia din Kansas City, chestionarul EuroQol 5 Dimensiuni ale s\u0103n\u0103t\u0103\u021bii \u0219i chestionarul Asocia\u021biei Inimii din New York).<\/p>\n

De asemenea, va exista un chestionar care va \u00eentreba cum \u00eei afecteaz\u0103 insuficien\u021ba cardiac\u0103 din punct de vedere financiar pe ei \u0219i pe \u00eengrijitorii lor. Persoanele care particip\u0103 la studiu vor fi rugate s\u0103 completeze aceste chestionare \u00eenainte de \u00eenceperea studiului, apoi la 3, 6, 9 luni \u0219i un an (c\u00e2nd se \u00eencheie studiul).<\/p>\n

Credem c\u0103 completarea chestionarelor va dura aproximativ 35 de minute \u0219i vom compensa participan\u021bii cu 10 lire sterline pentru timpul acordat fiec\u0103rui set de chestionare.<\/p>\n

Cu permisiunea lor, vom folosi dosarul lor medical pentru a afla despre program\u0103rile la asisten\u021b\u0103 medical\u0103, intern\u0103rile \u00een spital \u0219i rata de supravie\u021buire. Pentru a facilita participarea la studiu a persoanelor cu insuficien\u021b\u0103 cardiac\u0103, nu le vom cere s\u0103 mearg\u0103 la spital sau la cabinetul medicului de familie pentru nicio vizit\u0103 la studiu.<\/p>\n

Ace\u0219tia vor primi informa\u021bii despre studiu prin po\u0219t\u0103, medicul lor de familie sau asistenta medical\u0103 \u00eei va suna pentru a le explica studiul, iar medicamentele studiate le vor fi trimise direct acas\u0103.<\/p>\n

Persoanele care particip\u0103 la studiu vor avea mai multe op\u021biuni pentru completarea chestionarelor: online, telefonic sau fa\u021b\u0103 \u00een fa\u021b\u0103 la cabinetul medicului lor de familie.<\/p>\n

Cine conduce cercetarea?<\/h2>\n

Dr. Maria Pufulete<\/a>, Cercet\u0103tor senior, Universitatea din Bristol \u0219i Dr. Rachel Johnson<\/a>, Profesor asociat \u00een asisten\u021b\u0103 medical\u0103 primar\u0103, Universitatea din Bristol.<\/p>\n

Informa\u021bii suplimentare:<\/h2>\n

Pentru mai multe informa\u021bii sau pentru a v\u0103 implica \u00een acest proiect, trimite\u021bi un e-mail la bnssg.research@nhs.net<\/a>.<\/p>\n

Opiniile exprimate sunt cele ale autorului (autorilor) \u0219i nu neap\u0103rat cele ale NIHR sau ale Departamentului de S\u0103n\u0103tate \u0219i Asisten\u021b\u0103 Social\u0103.<\/p>\n <\/div>\r\n <\/section><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Section titled module-1 The effectiveness and cost effectiveness of coenzyme Q10 in heart failure with reduced ejection fraction: a pragmatic, patient-centred, data-enabled trial in primary care (CORAL)   Funding National Institute for Health and Care Research (NIHR) Health Technology Assessment (HTA) Ref. NIHR152257. What is the problem? Heart failure means the heart can\u2019t pump blood […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":32881,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"class_list":["post-34548","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/pages\/34548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/comments?post=34548"}],"version-history":[{"count":3,"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/pages\/34548\/revisions"}],"predecessor-version":[{"id":36179,"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/pages\/34548\/revisions\/36179"}],"up":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/pages\/32881"}],"wp:attachment":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/media?parent=34548"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/ro\/wp-json\/wp\/v2\/tags?post=34548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}