{"id":34466,"date":"2024-11-26T16:34:32","date_gmt":"2024-11-26T16:34:32","guid":{"rendered":"https:\/\/bnssghealthiertogether.org.uk\/?page_id=34466"},"modified":"2025-01-16T10:16:57","modified_gmt":"2025-01-16T10:16:57","slug":"athena-amitritypline-for-the-prevention-of-post-herpetic-neuralgia","status":"publish","type":"page","link":"https:\/\/bnssghealthiertogether.org.uk\/sq\/integrated-care-board\/research-and-evidence\/our-research-portfolio\/nihr-funded-projects\/athena-amitritypline-for-the-prevention-of-post-herpetic-neuralgia\/","title":{"rendered":"ATHENA: AmiTritiplin\u00eb p\u00ebr parandalimin e nevralgjis\u00eb post-HERPETIKE"},"content":{"rendered":"
Seksioni me titull module-1<\/span><\/a>
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ATHENA: AmiTritiplin\u00eb p\u00ebr parandalimin e nevralgjis\u00eb post-HERPETIKE<\/h1>\n<\/div>\n<\/header>\n
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<\/h2>\n

Financimi<\/h2>\n<\/article>\n

Instituti Komb\u00ebtar p\u00ebr Sh\u00ebndet\u00ebsi (NIHR) Vler\u00ebsimi i Teknologjis\u00eb Sh\u00ebndet\u00ebsore (HTA) Ref. NIHR129720<\/p>\n

Cila \u00ebsht\u00eb pyetja k\u00ebrkimore?<\/h2>\n

Cili \u00ebsht\u00eb efektiviteti i amitriptylin\u00ebs profilaktike me doz\u00eb t\u00eb ul\u00ebt p\u00ebr parandalimin e nevralgjis\u00eb postherpetike tek pacient\u00ebt e diagnostikuar me herpes zoster?<\/p>\n

Cili \u00ebsht\u00eb problemi?<\/h2>\n

Herpesi shkaktohet nga i nj\u00ebjti virus q\u00eb shkakton lin\u00eb e dhenve. Ai \u201cfle\u201d n\u00eb qelizat nervore p\u00ebr dekada t\u00eb t\u00ebra. Kur \u201czgjohet\u201d, mund t\u2019i b\u00ebj\u00eb njer\u00ebzit t\u00eb ndihen keq n\u00eb p\u00ebrgjith\u00ebsi, duke shkaktuar ndjesi shpimi gjilp\u00ebrash ose dhimbje n\u00eb nj\u00eb pjes\u00eb t\u00eb trupit, e ndjekur disa dit\u00eb m\u00eb von\u00eb nga nj\u00eb skuqje. Skuqja mund t\u00eb zgjas\u00eb deri n\u00eb 4 jav\u00eb p\u00ebr t\u2019u sh\u00ebruar.<\/p>\n

Ila\u00e7et antivirale ndihmojn\u00eb n\u00eb zvog\u00eblimin e dhimbjes fillestare dhe ashp\u00ebrsis\u00eb s\u00eb skuqjes. Disa njer\u00ebz mund t\u00eb ken\u00eb "dhimbje nervore" t\u00eb quajtur nevralgji post-herpetike muaj pasi skuqja e herpesit t\u00eb jet\u00eb zhdukur. Ne nuk kemi trajtime p\u00ebr ta parandaluar k\u00ebt\u00eb.<\/p>\n

Pacient\u00ebt blejn\u00eb dhe mjek\u00ebt e familjes u p\u00ebrshkruajn\u00eb qet\u00ebsues dhimbjesh si paracetamoli, por ato shpesh nuk ndihmojn\u00eb. Amitriptilina \u00ebsht\u00eb nj\u00eb ila\u00e7 i vjet\u00ebr, i p\u00ebrdorur fillimisht n\u00eb doza t\u00eb larta (75-150 mg) p\u00ebr t\u00eb trajtuar depresionin, por tani p\u00ebrdoret n\u00eb doza t\u00eb ul\u00ebta p\u00ebr dhimbjet nervore. Nj\u00eb studim i vog\u00ebl i botuar n\u00eb vitin 1997 sugjeroi q\u00eb marrja e nj\u00eb doze t\u00eb ul\u00ebt (25 mg) amitriptilin\u00eb n\u00eb fazat e hershme mund t\u00eb ndihmoj\u00eb n\u00eb parandalimin e nevralgjis\u00eb postherpetike.<\/p>\n

Cili \u00ebsht\u00eb q\u00ebllimi i hulumtimit?<\/h2>\n

Ne duam t\u00eb b\u00ebjm\u00eb nj\u00eb studim m\u00eb t\u00eb gjer\u00eb p\u00ebr t\u00eb zbuluar n\u00ebse p\u00ebrdorimi i amitriptylin\u00ebs kur shfaqet skuqja e par\u00eb parandalon dhimbjen m\u00eb von\u00eb. N\u00ebse fillimi i amitriptylin\u00ebs n\u00eb fazat e hershme ndihmon, \u00ebsht\u00eb nj\u00eb ila\u00e7 i lir\u00eb q\u00eb do t\u00eb parandalonte dhimbjen e zgjatur dhe t\u00eb v\u00ebshtir\u00eb p\u00ebr t'u trajtuar p\u00ebr mij\u00ebra njer\u00ebz.<\/p>\n

Megjithat\u00eb, amitriptilina zakonisht shkakton efekte an\u00ebsore si marramendje, goj\u00eb t\u00eb that\u00eb dhe kapsll\u00ebk. Mund t\u00eb shkaktoj\u00eb gjithashtu probleme kur p\u00ebrdoret s\u00eb bashku me disa ila\u00e7e t\u00eb tjera. Ky studim \u00ebsht\u00eb i nevojsh\u00ebm n\u00eb m\u00ebnyr\u00eb q\u00eb t\u00eb jemi t\u00eb sigurt se \u00e7do p\u00ebrfitim i tejkalon d\u00ebmin.<\/p>\n

Si do t\u00eb arrihet kjo?<\/h2>\n

Ne do t\u00eb rekrutojm\u00eb 846 persona t\u00eb mosh\u00ebs >50 vje\u00e7, t\u00eb diagnostikuar nga mjeku i tyre i familjes me herpes zoster brenda 72 or\u00ebve nga shfaqja e skuqjes.<\/p>\n

Do t'u k\u00ebrkojm\u00eb t\u00eb gjith\u00ebve t\u00eb marrin tableta \u00e7do nat\u00eb p\u00ebr 10 jav\u00eb: gjysm\u00ebs do t'i jepet amitriptilin\u00eb dhe gjysm\u00ebs tjet\u00ebr do t\u00eb marr\u00eb tableta placebo (ose "manual").<\/p>\n

As pacient\u00ebt dhe as mjek\u00ebt e tyre nuk mund t\u00eb zgjedhin se n\u00eb cilin grup b\u00ebjn\u00eb pjes\u00eb. Kjo do t\u00eb b\u00ebhet me an\u00eb t\u00eb nj\u00eb procesi t\u00eb kompjuterizuar t\u00eb quajtur "randomizim" - si hedhja e nj\u00eb zari p\u00ebr t\u00eb vendosur. N\u00eb k\u00ebt\u00eb m\u00ebnyr\u00eb, rezultatet nuk mund t\u00eb ndikohen nga bindjet e askujt n\u00eb lidhje me amitriptilin\u00ebn.<\/p>\n

I gjith\u00eb kujdesi tjet\u00ebr do t\u00eb jet\u00eb i nj\u00ebjt\u00eb - mjek\u00ebt e p\u00ebrgjithsh\u00ebm do t\u00eb p\u00ebrshkruajn\u00eb ila\u00e7e antivirale dhe qet\u00ebsues dhimbjesh n\u00ebse \u00ebsht\u00eb e nevojshme. Do t\u00eb p\u00ebrdorim pyet\u00ebsor\u00eb p\u00ebr t\u00eb kuptuar se \u00e7far\u00eb u ndodh t\u00eb gjith\u00ebve gjat\u00eb 12 muajve n\u00eb vijim, ve\u00e7an\u00ebrisht n\u00ebse ata ende kan\u00eb dhimbje t\u00eb lidhura me herpesin zoster n\u00eb 3 muaj.<\/p>\n

Kush po e udh\u00ebheq hulumtimin?<\/h2>\n

Dr. Matthew Ridd, mjek i p\u00ebrgjithsh\u00ebm dhe ligj\u00ebrues n\u00eb Kujdesin Sh\u00ebndet\u00ebsor Par\u00ebsor, Shkencat e Sh\u00ebndetit t\u00eb Popullsis\u00eb, Universiteti i Bristolit.<\/p>\n

Informacione t\u00eb m\u00ebtejshme:<\/h2>\n

Dr. Matthew Ridd<\/a><\/p>\n

P\u00ebr m\u00eb shum\u00eb informacion ose p\u00ebr t'u p\u00ebrfshir\u00eb n\u00eb k\u00ebt\u00eb projekt, d\u00ebrgoni email bnssg.research@nhs.net<\/a>.<\/p>\n

Pik\u00ebpamjet e shprehura jan\u00eb ato t\u00eb autorit\/autor\u00ebve dhe jo domosdoshm\u00ebrisht ato t\u00eb NIHR ose t\u00eb Departamentit t\u00eb Sh\u00ebndet\u00ebsis\u00eb dhe Kujdesit Social.<\/p>\n <\/div>\r\n <\/section><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Section titled module-1 ATHENA: AmiTritypline for the prevention of post-HErpetic NeuralgiA Funding National Institute for Health (NIHR) Health Technology Assessment (HTA) Ref. NIHR129720 What is the research question? What is the effectiveness of prophylactic low-dose amitriptyline for the prevention of post-herpetic neuralgia in patients diagnosed with herpes zoster? What is the problem? Shingles is caused […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":32881,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"class_list":["post-34466","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/sq\/wp-json\/wp\/v2\/pages\/34466","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/sq\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/sq\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/sq\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/sq\/wp-json\/wp\/v2\/comments?post=34466"}],"version-history":[{"count":3,"href":"https:\/\/bnssghealthiertogether.org.uk\/sq\/wp-json\/wp\/v2\/pages\/34466\/revisions"}],"predecessor-version":[{"id":36104,"href":"https:\/\/bnssghealthiertogether.org.uk\/sq\/wp-json\/wp\/v2\/pages\/34466\/revisions\/36104"}],"up":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/sq\/wp-json\/wp\/v2\/pages\/32881"}],"wp:attachment":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/sq\/wp-json\/wp\/v2\/media?parent=34466"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/sq\/wp-json\/wp\/v2\/tags?post=34466"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}