{"id":34466,"date":"2024-11-26T16:34:32","date_gmt":"2024-11-26T16:34:32","guid":{"rendered":"https:\/\/bnssghealthiertogether.org.uk\/?page_id=34466"},"modified":"2025-01-16T10:16:57","modified_gmt":"2025-01-16T10:16:57","slug":"athena-amitritypline-for-the-prevention-of-post-herpetic-neuralgia","status":"publish","type":"page","link":"https:\/\/bnssghealthiertogether.org.uk\/tr\/integrated-care-board\/research-and-evidence\/our-research-portfolio\/nihr-funded-projects\/athena-amitritypline-for-the-prevention-of-post-herpetic-neuralgia\/","title":{"rendered":"ATHENA: Herpes Sonras\u0131 Nevraljinin \u00d6nlenmesi \u0130\u00e7in AmiTritiplin"},"content":{"rendered":"
Mod\u00fcl-1 ba\u015fl\u0131kl\u0131 b\u00f6l\u00fcm<\/span><\/a>
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ATHENA: Herpes Sonras\u0131 Nevraljinin \u00d6nlenmesi \u0130\u00e7in AmiTritiplin<\/h1>\n<\/div>\n<\/header>\n
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Finansman<\/h2>\n<\/article>\n

Ulusal Sa\u011fl\u0131k Enstit\u00fcs\u00fc (NIHR) Sa\u011fl\u0131k Teknolojisi De\u011ferlendirmesi (HTA) Referans No: NIHR129720<\/p>\n

Ara\u015ft\u0131rma sorusu nedir?<\/h2>\n

Herpes zoster tan\u0131s\u0131 konmu\u015f hastalarda postherpetik nevraljinin \u00f6nlenmesinde d\u00fc\u015f\u00fck doz amitriptilin profilaktik tedavisinin etkinli\u011fi nedir?<\/p>\n

Sorun nedir?<\/h2>\n

Zona, su\u00e7i\u00e7e\u011fine neden olan vir\u00fcs\u00fcn ayn\u0131s\u0131 taraf\u0131ndan olu\u015fur. Vir\u00fcs, sinir h\u00fccrelerinde on y\u0131llarca "uykuda" kal\u0131r. "Uyand\u0131\u011f\u0131nda", insanlar\u0131n genel olarak kendilerini iyi hissetmemelerine, v\u00fccudun bir b\u00f6lgesinde kar\u0131ncalanma veya a\u011fr\u0131ya neden olabilir ve birka\u00e7 g\u00fcn sonra d\u00f6k\u00fcnt\u00fc ortaya \u00e7\u0131kar. D\u00f6k\u00fcnt\u00fcn\u00fcn iyile\u015fmesi 4 haftaya kadar s\u00fcrebilir.<\/p>\n

Antiviral ila\u00e7lar, ba\u015flang\u0131\u00e7taki a\u011fr\u0131y\u0131 ve d\u00f6k\u00fcnt\u00fcn\u00fcn \u015fiddetini azaltmaya yard\u0131mc\u0131 olur. Baz\u0131 ki\u015filerde, zona d\u00f6k\u00fcnt\u00fcs\u00fc ge\u00e7tikten aylar sonra bile "sinir a\u011fr\u0131s\u0131" olarak adland\u0131r\u0131lan postherpetik nevralji g\u00f6r\u00fclebilir. Bunu \u00f6nleyecek herhangi bir tedavi y\u00f6ntemimiz yok.<\/p>\n

Hastalar parasetamol gibi a\u011fr\u0131 kesiciler sat\u0131n al\u0131yor ve pratisyen hekimler de re\u00e7ete ediyor, ancak bunlar genellikle i\u015fe yaram\u0131yor. Amitriptilin eski bir ila\u00e7 olup, ba\u015flang\u0131\u00e7ta y\u00fcksek dozlarda (75-150 mg) depresyon tedavisinde kullan\u0131l\u0131yordu, ancak \u015fimdi d\u00fc\u015f\u00fck dozlarda sinir a\u011fr\u0131s\u0131 i\u00e7in kullan\u0131l\u0131yor. 1997'de yay\u0131nlanan k\u00fc\u00e7\u00fck bir \u00e7al\u0131\u015fma, erken d\u00f6nemde d\u00fc\u015f\u00fck dozda (25 mg) amitriptilin alman\u0131n zona sonras\u0131 nevraljiyi \u00f6nlemeye yard\u0131mc\u0131 olabilece\u011fini \u00f6ne s\u00fcrd\u00fc.<\/p>\n

Ara\u015ft\u0131rman\u0131n amac\u0131 nedir?<\/h2>\n

D\u00f6k\u00fcnt\u00fc ilk ortaya \u00e7\u0131kt\u0131\u011f\u0131nda amitriptilin kullanman\u0131n daha sonraki a\u011fr\u0131y\u0131 \u00f6nleyip \u00f6nlemedi\u011fini \u00f6\u011frenmek i\u00e7in daha b\u00fcy\u00fck bir \u00e7al\u0131\u015fma yapmak istiyoruz. E\u011fer amitriptilin kullan\u0131m\u0131na erken ba\u015flanmas\u0131 ger\u00e7ekten yard\u0131mc\u0131 oluyorsa, bu binlerce insan i\u00e7in uzun s\u00fcreli ve tedavisi zor a\u011fr\u0131lar\u0131 \u00f6nleyecek ucuz bir ila\u00e7 olacakt\u0131r.<\/p>\n

Ancak amitriptilin s\u0131kl\u0131kla ba\u015f d\u00f6nmesi, a\u011f\u0131z kurulu\u011fu ve kab\u0131zl\u0131k gibi yan etkilere neden olur. Ayr\u0131ca baz\u0131 di\u011fer ila\u00e7larla birlikte kullan\u0131ld\u0131\u011f\u0131nda da sorunlara yol a\u00e7abilir. Bu \u00e7al\u0131\u015fma, faydalar\u0131n\u0131n zararlar\u0131ndan daha fazla olup olmad\u0131\u011f\u0131ndan emin olabilmemiz i\u00e7in gereklidir.<\/p>\n

Bu nas\u0131l ba\u015far\u0131lacak?<\/h2>\n

D\u00f6k\u00fcnt\u00fcn\u00fcn ortaya \u00e7\u0131kmas\u0131ndan sonraki 72 saat i\u00e7inde aile hekimleri taraf\u0131ndan zona te\u015fhisi konulmu\u015f 50 ya\u015f \u00fcst\u00fc 846 ki\u015fiyi \u00e7al\u0131\u015fmaya dahil edece\u011fiz.<\/p>\n

Herkese 10 hafta boyunca her gece tablet almalar\u0131n\u0131 rica edece\u011fiz: Yar\u0131s\u0131na amitriptilin, di\u011fer yar\u0131s\u0131na ise plasebo (veya "sahte") tablet verilecek.<\/p>\n

Ne hastalar ne de doktorlar\u0131 hangi gruba dahil olacaklar\u0131n\u0131 se\u00e7emezler. Bu, "rastgelele\u015ftirme" ad\u0131 verilen bilgisayarl\u0131 bir i\u015flemle yap\u0131l\u0131r \u2013 t\u0131pk\u0131 karar vermek i\u00e7in zar atmak gibi. Bu \u015fekilde sonu\u00e7lar, amitriptilin hakk\u0131ndaki herhangi bir ki\u015finin inanc\u0131ndan etkilenemez.<\/p>\n

Di\u011fer t\u00fcm bak\u0131m ayn\u0131 kalacak; gerekirse pratisyen hekimler antiviral ila\u00e7lar ve a\u011fr\u0131 kesiciler re\u00e7ete edecek. \u00d6n\u00fcm\u00fczdeki 12 ay boyunca herkesin durumunu, \u00f6zellikle de 3 ay sonra zona ile ilgili a\u011fr\u0131lar\u0131n\u0131n devam edip etmedi\u011fini anlamak i\u00e7in anketler kullanaca\u011f\u0131z.<\/p>\n

Ara\u015ft\u0131rmay\u0131 kim y\u00fcr\u00fct\u00fcyor?<\/h2>\n

Dr. Matthew Ridd, Aile Hekimi ve Bristol \u00dcniversitesi Halk Sa\u011fl\u0131\u011f\u0131 Bilimleri B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00dcyesi.<\/p>\n

Daha fazla bilgi:<\/h2>\n

Dr. Matthew Ridd<\/a><\/p>\n

Daha fazla bilgi almak veya bu projeye kat\u0131lmak i\u00e7in l\u00fctfen e-posta g\u00f6nderin. bnssg.research@nhs.net<\/a>.<\/p>\n

Burada ifade edilen g\u00f6r\u00fc\u015fler yazar(lar)a aittir ve NIHR veya Sa\u011fl\u0131k ve Sosyal Bak\u0131m Bakanl\u0131\u011f\u0131'n\u0131n g\u00f6r\u00fc\u015flerini yans\u0131tmayabilir.<\/p>\n <\/div>\r\n <\/section><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Section titled module-1 ATHENA: AmiTritypline for the prevention of post-HErpetic NeuralgiA Funding National Institute for Health (NIHR) Health Technology Assessment (HTA) Ref. NIHR129720 What is the research question? What is the effectiveness of prophylactic low-dose amitriptyline for the prevention of post-herpetic neuralgia in patients diagnosed with herpes zoster? What is the problem? Shingles is caused […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":32881,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"class_list":["post-34466","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages\/34466","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/comments?post=34466"}],"version-history":[{"count":3,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages\/34466\/revisions"}],"predecessor-version":[{"id":36104,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages\/34466\/revisions\/36104"}],"up":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages\/32881"}],"wp:attachment":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/media?parent=34466"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/tags?post=34466"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}