{"id":34548,"date":"2024-11-26T16:46:57","date_gmt":"2024-11-26T16:46:57","guid":{"rendered":"https:\/\/bnssghealthiertogether.org.uk\/?page_id=34548"},"modified":"2025-01-16T22:41:05","modified_gmt":"2025-01-16T22:41:05","slug":"the-effectiveness-and-cost-effectiveness-of-coenzyme-q10-in-heart-failure-with-reduced-ejection-fraction-a-pragmatic-patient-centred-data-enabled-trial-in-primary-care-coral","status":"publish","type":"page","link":"https:\/\/bnssghealthiertogether.org.uk\/tr\/integrated-care-board\/research-and-evidence\/our-research-portfolio\/nihr-funded-projects\/the-effectiveness-and-cost-effectiveness-of-coenzyme-q10-in-heart-failure-with-reduced-ejection-fraction-a-pragmatic-patient-centred-data-enabled-trial-in-primary-care-coral\/","title":{"rendered":"Azalm\u0131\u015f ejeksiyon fraksiyonlu kalp yetmezli\u011finde koenzim Q10'un etkinli\u011fi ve maliyet etkinli\u011fi: birinci basamak sa\u011fl\u0131k hizmetlerinde pragmatik, hasta merkezli, veriye dayal\u0131 bir \u00e7al\u0131\u015fma (CORAL)"},"content":{"rendered":"
Mod\u00fcl-1 ba\u015fl\u0131kl\u0131 b\u00f6l\u00fcm<\/span><\/a>
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Azalm\u0131\u015f kalp yetmezli\u011finde koenzim Q10'un etkinli\u011fi ve maliyet etkinli\u011fi
\nEjeksiyon fraksiyonu: Birinci basamak sa\u011fl\u0131k hizmetlerinde pragmatik, hasta merkezli, veriye dayal\u0131 bir \u00e7al\u0131\u015fma (CORAL)<\/h1>\n

 <\/p>\n

\n

Finansman<\/h2>\n<\/article>\n

Ulusal Sa\u011fl\u0131k ve Bak\u0131m Ara\u015ft\u0131rma Enstit\u00fcs\u00fc (NIHR) Sa\u011fl\u0131k Teknolojisi De\u011ferlendirmesi (HTA) Referans No: NIHR152257.<\/p>\n

Sorun nedir?<\/h2>\n

Kalp yetmezli\u011fi, kalbin \u00e7ok zay\u0131f veya \u00e7ok sert olmas\u0131 nedeniyle kan\u0131 d\u00fczg\u00fcn bir \u015fekilde pompalayamamas\u0131 anlam\u0131na gelir. Kalp yetmezli\u011fi olan ki\u015filer genellikle nefes darl\u0131\u011f\u0131 ve yorgunluk hissederler. Ayaklar\u0131 ve bilekleri \u015fi\u015fer. Bu belirtiler ya\u015fam kalitesinin d\u00fc\u015fmesine yol a\u00e7abilir.<\/p>\n

Kalp yetmezli\u011fi olan ki\u015filer ve sa\u011fl\u0131k uzmanlar\u0131, ya\u015fam kalitesini iyile\u015ftirebilecek \u015feyleri anlamaya y\u00f6nelik ara\u015ft\u0131rmalar\u0131n kendileri i\u00e7in en \u00f6nemli \u015fey oldu\u011funu s\u00f6yl\u00fcyor.<\/p>\n

Kalp yetmezli\u011fi, kalbin taranmas\u0131 (ekokardiyogram) yoluyla te\u015fhis edilir. Bu tarama, her kalp at\u0131\u015f\u0131nda kalbin ana pompalama odas\u0131ndan d\u0131\u015far\u0131 at\u0131lan kan miktar\u0131n\u0131 \u00f6l\u00e7en "ejeksiyon fraksiyonu"nu belirler.<\/p>\n

Kalp yetmezli\u011fi olan baz\u0131 ki\u015filerde ejeksiyon fraksiyonu normaldir, ancak bu ara\u015ft\u0131rma ejeksiyon fraksiyonu d\u00fc\u015f\u00fck olan kalp yetmezli\u011fi hastalar\u0131na odaklanmaktad\u0131r.<\/p>\n

Ara\u015ft\u0131rman\u0131n amac\u0131 nedir?<\/h2>\n

\u00c7al\u0131\u015fman\u0131n temel amac\u0131, koenzim Q10'un ya\u015fam kalitesini iyile\u015ftirip iyile\u015ftirmedi\u011fini ortaya \u00e7\u0131karmakt\u0131r. Koenzim Q10, v\u00fccutta ve baz\u0131 g\u0131dalarda do\u011fal olarak bulunan, vitamin benzeri bir maddedir.<\/p>\n

Kalp yetmezli\u011fi ve d\u00fc\u015f\u00fck ejeksiyon fraksiyonu olan ki\u015filerde koenzim Q10 alman\u0131n faydal\u0131 olup olmad\u0131\u011f\u0131n\u0131 belirlemek i\u00e7in bir \u00e7al\u0131\u015fma y\u00fcr\u00fctmek istiyoruz.<\/p>\n

Bu nas\u0131l ba\u015far\u0131lacak?<\/h2>\n

Bunu, kat\u0131l\u0131mc\u0131lardan anket doldurmalar\u0131n\u0131 isteyerek \u00f6\u011frenece\u011fiz. Anketler, ya\u015fam kaliteleri ve g\u00fcnl\u00fck ya\u015famlar\u0131 hakk\u0131nda sorular i\u00e7erecektir (Kansas City Kardiyomiyopati Anketi, EuroQol 5 Boyutlu Sa\u011fl\u0131k Anketi ve New York Kalp Derne\u011fi Anketi).<\/p>\n

Ayr\u0131ca, kalp yetmezli\u011finin kendilerini ve bak\u0131c\u0131lar\u0131n\u0131 mali a\u00e7\u0131dan nas\u0131l etkiledi\u011fini soran bir anket de olacak. \u00c7al\u0131\u015fmaya kat\u0131lan ki\u015filerden, \u00e7al\u0131\u015fma ba\u015flamadan \u00f6nce, ard\u0131ndan 3, 6, 9 ay sonra ve bir y\u0131l sonra (\u00e7al\u0131\u015fma sona erdi\u011finde) bu anketleri doldurmalar\u0131 istenecek.<\/p>\n

Anketlerin doldurulmas\u0131n\u0131n yakla\u015f\u0131k 35 dakika s\u00fcrece\u011fini d\u00fc\u015f\u00fcn\u00fcyoruz ve her anket seti i\u00e7in kat\u0131l\u0131mc\u0131lara zamanlar\u0131 kar\u015f\u0131l\u0131\u011f\u0131nda 10 sterlin \u00f6deme yapaca\u011f\u0131z.<\/p>\n

\u0130zinleri do\u011frultusunda, sa\u011fl\u0131k randevular\u0131, hastane yat\u0131\u015flar\u0131 ve hayatta kalma oranlar\u0131 hakk\u0131nda bilgi edinmek i\u00e7in t\u0131bbi kay\u0131tlar\u0131n\u0131 kullanaca\u011f\u0131z. Kalp yetmezli\u011fi olan ki\u015filerin \u00e7al\u0131\u015fmaya kat\u0131lmas\u0131n\u0131 kolayla\u015ft\u0131rmak i\u00e7in, \u00e7al\u0131\u015fma ziyaretleri i\u00e7in hastanelerine veya aile hekimlerine gitmelerini istemeyece\u011fiz.<\/p>\n

\u00c7al\u0131\u015fma hakk\u0131nda bilgi kendilerine posta yoluyla g\u00f6nderilecek, aile hekimleri veya hem\u015fireleri kendilerini telefonla arayarak \u00e7al\u0131\u015fmay\u0131 a\u00e7\u0131klayacak ve \u00e7al\u0131\u015fma ila\u00e7lar\u0131 do\u011frudan evlerine g\u00f6nderilecektir.<\/p>\n

\u00c7al\u0131\u015fmaya kat\u0131lan ki\u015filerin anketlerini tamamlamak i\u00e7in \u00e7e\u015fitli se\u00e7enekleri olacak: \u00e7evrimi\u00e7i, telefonla veya aile hekimli\u011fi muayenehanelerinde y\u00fcz y\u00fcze.<\/p>\n

Ara\u015ft\u0131rmay\u0131 kim y\u00fcr\u00fct\u00fcyor?<\/h2>\n

Dr. Maria Pufulete<\/a>, Bristol \u00dcniversitesi K\u0131demli Ara\u015ft\u0131rma G\u00f6revlisi ve Dr. Rachel Johnson<\/a>, Bristol \u00dcniversitesi Birinci Basamak Sa\u011fl\u0131k Hizmetleri B\u00f6l\u00fcm\u00fc Do\u00e7enti.<\/p>\n

Daha fazla bilgi:<\/h2>\n

Daha fazla bilgi almak veya bu projeye kat\u0131lmak i\u00e7in l\u00fctfen e-posta g\u00f6nderin. bnssg.research@nhs.net<\/a>.<\/p>\n

Burada ifade edilen g\u00f6r\u00fc\u015fler yazar(lar)a aittir ve NIHR veya Sa\u011fl\u0131k ve Sosyal Bak\u0131m Bakanl\u0131\u011f\u0131'n\u0131n g\u00f6r\u00fc\u015flerini yans\u0131tmayabilir.<\/p>\n <\/div>\r\n <\/section><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Section titled module-1 The effectiveness and cost effectiveness of coenzyme Q10 in heart failure with reduced ejection fraction: a pragmatic, patient-centred, data-enabled trial in primary care (CORAL)   Funding National Institute for Health and Care Research (NIHR) Health Technology Assessment (HTA) Ref. NIHR152257. What is the problem? Heart failure means the heart can\u2019t pump blood […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":32881,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"class_list":["post-34548","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages\/34548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/comments?post=34548"}],"version-history":[{"count":3,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages\/34548\/revisions"}],"predecessor-version":[{"id":36179,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages\/34548\/revisions\/36179"}],"up":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages\/32881"}],"wp:attachment":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/media?parent=34548"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/tags?post=34548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}