{"id":34699,"date":"2024-11-26T17:12:53","date_gmt":"2024-11-26T17:12:53","guid":{"rendered":"https:\/\/bnssghealthiertogether.org.uk\/?page_id=34699"},"modified":"2024-11-26T17:12:53","modified_gmt":"2024-11-26T17:12:53","slug":"what-is-the-most-efficacious-acceptable-and-cost-effective-way-to-screen-for-liver-disease-in-the-community","status":"publish","type":"page","link":"https:\/\/bnssghealthiertogether.org.uk\/tr\/integrated-care-board\/research-and-evidence\/our-research-portfolio\/type-2-rcf-funded-projects\/what-is-the-most-efficacious-acceptable-and-cost-effective-way-to-screen-for-liver-disease-in-the-community\/","title":{"rendered":"Toplumda karaci\u011fer hastal\u0131\u011f\u0131n\u0131 taraman\u0131n en etkili, kabul edilebilir ve maliyet a\u00e7\u0131s\u0131ndan en uygun yolu nedir?"},"content":{"rendered":"
Mod\u00fcl-1 ba\u015fl\u0131kl\u0131 b\u00f6l\u00fcm<\/span><\/a>
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Toplumda karaci\u011fer hastal\u0131\u011f\u0131n\u0131 taramak i\u00e7in en etkili, kabul edilebilir ve maliyet etkin y\u00f6ntem hangisidir?<\/h1>\n

Finansman:<\/h1>\n

BNSSG ICB Ara\u015ft\u0131rma Kapasitesi Geli\u015ftirme Fonu.<\/p>\n

Sorun nedir?<\/h2>\n

Karaci\u011fer hastal\u0131klar\u0131n\u0131n %'si \u00f6nlenebilir ve alkol, obezite veya vir\u00fcslerden kaynaklan\u0131r. Buna ra\u011fmen, di\u011fer b\u00fcy\u00fck \u00f6l\u00fcm nedenleri azal\u0131rken, karaci\u011fer hastal\u0131\u011f\u0131na ba\u011fl\u0131 \u00f6l\u00fcmler artmaya devam etmektedir. Karaci\u011fer hastal\u0131\u011f\u0131, Birle\u015fik Krall\u0131k'ta \u00e7al\u0131\u015fma \u00e7a\u011f\u0131ndaki insanlar\u0131n ba\u015fl\u0131ca \u00f6l\u00fcm nedenlerinden biri olarak intihar\u0131 geride b\u0131rakm\u0131\u015ft\u0131r. Alkol, obezite ve vir\u00fcsler karaci\u011fere zarar vererek skar (fibrozis) olu\u015fmas\u0131na neden olabilir. Bu skarla\u015fma geri d\u00f6nd\u00fcr\u00fclemez hale geldi\u011finde siroz olarak adland\u0131r\u0131l\u0131r. Hastalar siroza yakaland\u0131ktan sonra, kafa kar\u0131\u015f\u0131kl\u0131\u011f\u0131, kar\u0131n b\u00f6lgesinde s\u0131v\u0131 birikmesi veya ba\u011f\u0131rsaklardan kanama gibi komplikasyon riskleri \u00e7ok daha y\u00fcksektir. Bununla birlikte, siroz veya k\u00f6t\u00fc karaci\u011fer skarla\u015fmas\u0131 (fibrozis) erken te\u015fhis edilirse, doktorlar hastalar\u0131 tedavi etmeye ba\u015flayabilir. Tedavi, ya\u015fam tarz\u0131 de\u011fi\u015fiklikleriyle destek, ila\u00e7 tedavisine ba\u015flama ve hastalar\u0131n karaci\u011fer kanseri a\u00e7\u0131s\u0131ndan izlenmesini i\u00e7erir. Ama\u00e7, hastalar\u0131n komplikasyon geli\u015ftirmesini \u00f6nlemektir.<\/p>\n

\u015eu anda hastalar\u0131n karaci\u011fer hastal\u0131\u011f\u0131 \u015f\u00fcphesi duymalar\u0131 ve bu nedenle test yapt\u0131rmalar\u0131 gerekiyor. Sorun \u015fu ki, hastalar sirozun komplikasyonlar\u0131 ortaya \u00e7\u0131kana kadar belirti g\u00f6stermiyorlar.<\/p>\n

Karaci\u011fer hastal\u0131\u011f\u0131n\u0131 ve sirozu tespit etmek i\u00e7in kan testleri ve \u00f6zel karaci\u011fer taramalar\u0131 da dahil olmak \u00fczere iyi testlerimiz var. Bilmedi\u011fimiz \u015fey ise (1) bu testleri sipari\u015f etmenin en iyi yolu, (2) insanlar\u0131 test etmenin en uygun maliyetli yolu, (3) en fazla karaci\u011fer hastal\u0131\u011f\u0131n\u0131 tespit edecek y\u00f6ntem ve (4) hastalar\u0131n izlemesi en kolay yol.<\/p>\n

Ara\u015ft\u0131rman\u0131n amac\u0131 nedir?<\/strong><\/h2>\n

Genel ama\u00e7, toplumda karaci\u011fer hastal\u0131\u011f\u0131 olan ki\u015fileri test etmek ve bu test sonu\u00e7lar\u0131n\u0131 hastalar\u0131n \u015fu anda ald\u0131\u011f\u0131 normal bak\u0131mla kar\u015f\u0131la\u015ft\u0131rmak i\u00e7in bir \u00e7al\u0131\u015fma tasarlamakt\u0131r. \u00c7al\u0131\u015fma, \u00fclke genelindeki birden fazla aile hekimli\u011fi klini\u011fi kullan\u0131larak y\u00fcr\u00fct\u00fclecektir.<\/p>\n

O zaman bu \u015fekilde toplumda karaci\u011fer hastal\u0131\u011f\u0131 taramas\u0131 yapman\u0131n genel olarak daha ucuz olup olmad\u0131\u011f\u0131n\u0131 test ederdik.<\/p>\n

Bu nas\u0131l ba\u015far\u0131lacak?<\/h2>\n

A\u015fama 1 \u2013 12 ayl\u0131k deneme s\u00fcreci.<\/em> \u00dclke genelindeki 38 aile hekimli\u011fi klini\u011fi kat\u0131lmaya davet edilecek. Her klinik rastgele se\u00e7ilerek "m\u00fcdahale grubu" veya "kontrol grubu"na dahil edilecek.<\/p>\n

\u201cM\u00fcdahale grubu\u201dnda, denemeye kat\u0131lma kriterlerini kar\u015f\u0131layan hastalardan rastgele se\u00e7ilen bir grup, kan testleri, karaci\u011fer taramalar\u0131 ve ek sa\u011fl\u0131k anketleri ile karaci\u011fer hastal\u0131\u011f\u0131 a\u00e7\u0131s\u0131ndan taranmaya davet edilecektir. Sorulacak sorular aras\u0131nda t\u00fcketilen alkol miktar\u0131 ve hastalar\u0131n sahip olabilece\u011fi di\u011fer sa\u011fl\u0131k sorunlar\u0131 yer alacakt\u0131r. Bu hastalar 1 y\u0131l boyunca takip edilecektir.<\/p>\n

Kriterleri kar\u015f\u0131layan hastalar\u0131n 40 ile 75 ya\u015f aras\u0131nda olmas\u0131 gerekmektedir. Y\u00fcksek karaci\u011fer kan test sonu\u00e7lar\u0131na, a\u015f\u0131r\u0131 alkol t\u00fcketimi \u00f6yk\u00fcs\u00fcne, tip 2 diyabete veya obeziteye sahip olmalar\u0131 gerekmektedir. Daha \u00f6nce bilinen karaci\u011fer hastal\u0131\u011f\u0131, kanser veya \u00f6l\u00fcmc\u00fcl hastal\u0131\u011f\u0131 olan hastalar \u00e7al\u0131\u015fmaya dahil edilmeyecektir.<\/p>\n

Kontrol grubuna dahil edilen hastalar\u0131, karaci\u011fer servislerine y\u00f6nlendirilip y\u00f6nlendirilmediklerini g\u00f6rmek i\u00e7in 1 y\u0131l boyunca takip edece\u011fiz.<\/p>\n

A\u015fama 2 \u2013 Analiz. 12 ayl\u0131k deneme s\u00fcrecinden elde etti\u011fimiz bilgiler do\u011frultusunda \u015fu sorular\u0131 yan\u0131tlayaca\u011f\u0131z:<\/p>\n

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  1. Sirozun ne kadar yayg\u0131n oldu\u011fu tespit edildi.<\/li>\n
  2. Sevk edilenlerin ne kadar\u0131nda ciddi karaci\u011fer hastal\u0131\u011f\u0131 yoktu?<\/li>\n
  3. Sevk edilen hastalardan ka\u00e7\u0131 ilk y\u0131l i\u00e7inde karaci\u011fer komplikasyonlar\u0131 nedeniyle hastaneye yat\u0131r\u0131ld\u0131?.<\/li>\n
  4. Deney yoluyla karaci\u011fer hastal\u0131\u011f\u0131n\u0131n tespit edilmesi, mevcut standart tedavi y\u00f6ntemine k\u0131yasla daha az maliyetli miydi?.<\/li>\n
  5. Hastalar, deneme s\u00fcrecinin uygun oldu\u011funu d\u00fc\u015f\u00fcnd\u00fcler mi?.<\/li>\n<\/ol>\n

    Ara\u015ft\u0131rmay\u0131 kim y\u00fcr\u00fct\u00fcyor?<\/strong><\/h2>\n

    Dr. Kushala Abeysekera, Halk Sa\u011fl\u0131\u011f\u0131 ve Epidemiyoloji Akademik Klinik \u00d6\u011fretim G\u00f6revlisi: Gastroenteroloji, Bristol T\u0131p Fak\u00fcltesi.<\/p>\n

    Daha fazla bilgi<\/h2>\n

    Hakk\u0131nda Dr. Kushala Abeysekera<\/a>.<\/p>\n

    Daha fazla bilgi almak veya bu projeye dahil olmak i\u00e7in l\u00fctfen ileti\u015fime ge\u00e7in.\u00a0bnssg.research@nhs.net<\/a>.<\/p>\n

    <\/h2>\n <\/div>\r\n <\/section><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

    Section titled module-1 What is the most efficacious, aceptable and cost effective way to screen for liver disease in the community? Funding: BNSSG ICB Research Capability Funding. What is the problem? 90% of all liver disease can be prevented and is either due to alcohol, obesity or viruses. Despite this, whilst all the other big […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":32896,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"class_list":["post-34699","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages\/34699","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/comments?post=34699"}],"version-history":[{"count":2,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages\/34699\/revisions"}],"predecessor-version":[{"id":34701,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages\/34699\/revisions\/34701"}],"up":[{"embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/pages\/32896"}],"wp:attachment":[{"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/media?parent=34699"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bnssghealthiertogether.org.uk\/tr\/wp-json\/wp\/v2\/tags?post=34699"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}